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CAS No. : 77-92-9
MCE 国际站:Citric acid
产品活性:Citric acid 是一种防腐剂和食品添加剂。Citric acid 诱导 HaCaT 细胞凋亡 (apoptosis),细胞周期阻滞于 G2/M 期和 S 期。Citric acid 通过降低抗氧化酶活性引起肝脏氧化损伤。Citric acid 对小鼠造成肾毒性。
研究领域:Apoptosis | Metabolic Enzyme/Protease | Anti-infection
作用靶点:Apoptosis | Endogenous Metabolite | Antibiotic
结构分类:酮、醛、酸 | 结构分类
In Vitro: Citric acid (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.
Citric acid (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.
Citric acid (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl.
In Vivo: Citric acid (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver.
Citric acid (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.
Citric acid (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice.
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