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CAS No. : 873857-62-6
MCE 国际站:Fidaxomicin
产品活性:Fidaxomicin (OPT-80) 是一种大环抗生素 (antibiotic),是一种口服有效的 RNA 聚合酶 (RNA polymerase) 抑制剂。Fidaxomicin 具有较窄的抗菌 (antibacterial)活性,较好的抗艰难梭菌活性 (MIC90=0.12 μg/mL)。Fidaxomicin 可用于艰难梭菌感染 (CDI) 研究。
研究领域:Cell Cycle/DNA Damage | Anti-infection | Apoptosis
作用靶点:DNA/RNA Synthesis | Bacterial | Apoptosis | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗菌 | 酚类 | 多酚类 | 抗生素 | 大环内脂类 | 结构分类
In Vitro: Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024 μg/mL).
In Vivo: Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis.
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