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CAS No. : 117-39-5
MCE 国际站:Quercetin
产品活性:Quercetin 是一种天然黄酮类化合物,可激活或抑制许多蛋白质的活性。Quercetin 可激活 SIRT1,也可抑制 PI3K,抑制 PI3Kγ,PI3Kδ,PI3Kβ 的 IC50 分别为 2.4 μM, 3.0 μM, 5.4 μM。
研究领域:PI3K/Akt/mTOR | Autophagy | NF-κB | Metabolic Enzyme/Protease | Immunology/Inflammation | Apoptosis
作用靶点:PI3K | Autophagy | Mitophagy | Reactive Oxygen Species | Apoptosis
结构分类:黄酮类 | 黄酮醇 | 结构分类
来源:植物 | 其他科
In Vitro: Quercetin is a type of plant-based chemical, or phytochemical, used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin strongly abrogates PI3K and Src kinases, mildly inhibits Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.
In Vivo: Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth.
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