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Norepinephrine bitartrate monohydrate

CAS No. : 108341-18-0

MCE 国际站：Norepinephrine bitartrate monohydrate

产品活性：Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate 是一种有效的肾上腺素能受体 (AR) 激动剂。Norepinephrine 可以激活 α₁、α₂、β₁ 受体。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Autophagy  |  Metabolic Enzyme/Protease

作用靶点：Adrenergic Receptor  |  Autophagy  |  Endogenous Metabolite

结构分类：酚类  |  结构分类

In Vitro: Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is generally considered to be a β₁-subtype selective adrenergic agonist over β₂-adrenoceptor. Norepinephrine(NE) bitartrate monohydrate also has direct activity at the β₂-adrenoceptor in higher concentrations.
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.

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