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Deoxyelephantopin

CAS No. : 29307-03-7

MCE 国际站：Deoxyelephantopin

产品活性：Deoxyelephantopin 是一种来自 Elephantopus scaber 的，具有生物活性的天然倍半萜烯内酯。可广泛用于癌症方面的研究。Deoxyelephantopin 抑制 NF-κB，MAPK，PI3K/Akt 和 β-catenin 信号传导。

研究领域：NF-κB

作用靶点：NF-κB

结构分类：萜类  |  倍半萜

来源：植物  |  豆科  |  紫穗槐  |  植物  |  菊科

In Vitro: Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC₅₀s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively.
Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells.

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