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Prostaglandin E1

CAS No. : 745-65-3

MCE 国际站：Prostaglandin E1

产品活性：Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP3、EP4、EP2、IP 和 EP1 的 K_i 值分别为 1.1 nM、2.1 nM、10 nM、33 nM 和 36 nM。Prostaglandin E1 诱导血管舒张并抑制血小板聚集。Prostaglandin E1 可作为血管扩张剂用于外周血管疾病的研究。

研究领域：GPCR/G Protein  |  Metabolic Enzyme/Protease

作用靶点：Prostaglandin Receptor  |  Endogenous Metabolite

结构分类：酮、醛、酸  |  结构分类

In Vitro: Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC₅₀ of 400 nM.
?Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC₅₀ of 500 nM.
?Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis.
?Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs.

In Vivo: Prostaglandin E1 (20 ng/animal/day; s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice.

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