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CAS No. : 126-17-0
MCE 国际站:Solasodine
产品活性:Solasodine (Purapuridine) 是类固醇生物碱,存在于茄科植物中。Solasodine 具有神经保护,抗真菌,降压,抗癌,抗动脉粥样硬化,抗雄激素和抗炎活性。
研究领域:Apoptosis | Anti-infection | Metabolic Enzyme/Protease
作用靶点:MDM-2/p53 | Fungal | E1/E2/E3 Enzyme | Apoptosis
结构分类:生物碱 | 哌啶类生物碱
来源:植物 | 茄科 | 龙葵
In Vitro: Solasodine (90 μM; 2 days) treatment displays significant sprouting in P19 cells. Solasodine induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine induces the differentiation of P19 cells, essentially towards the neuronal pathway.Solasodine induce apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins.
In Vivo: Solasodine (25-100 mg/kg; intraperitoneal injection; once) treatment significantly delays latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiates Thiopental-provoked sleep in a dose-dependent manner. Solasodine has anticonvulsant and CNS depressant activities.
Solasodine (375 μM; i.c.v.; for 2 weeks) treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells.
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