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MCE 国际站:IL-36 gamma/IL-1F9 Protein, Human (152a.a, His)
IL-36 gamma (IL-1F9) 是 IL-36 家族的其中一个亚型,属于 IL-1 超家族。IL-36 gamma 介导炎症反应。IL-36 gamma 与 IL-36R 结合并募集辅助受体 IL-1RAcP,由此激活 NF-κB 和 MAPK 信号通路,但这种激活需要中性粒细胞来源的蛋白酶对 IL-36 gamma 的 N 端进行切割。IL-36 gamma/IL-1F9 Protein, Human (152a.a, His) 是一种由 E. coli 产生的重组人 IL-36 gamma (S18-D169),带有 His 标签。
Synonyms: Interleukin-36 gamma; IL-36γ; IL36G; IL-1F9; IL-1H1
Species: Human
Source: E. coli
研究背景:IL-36 gamma (IL-1F9), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 gamma is expressed in peripheral blood lymphocytes, keratinocytes, bronchial epithelial cells and THP-1 cells.
The sequence of amino acids in IL-36 gamma differs in different species. Human IL-36 gamma shares <55% aa sequence identity with mouse.
IL-36 gamma has β-trefoil structure. L-36 gamma binds to IL-36R and recruits the co-receptor IL-1RAcP. So that heterodimeric signaling complex brings Toll/IL-1R (TIR) domains of the 2 receptor chains in close proximity, and thereby activating NF-κB and MAPK signaling pathways. But the activation requires N-terminal cleavage at Val1518 by neutrophil granule-derived proteases, such as cathepsin G, elastase and proteinase-3. IL-36 gamma is associated with chronic inflammation and cancers. IL-36 gamma is up-regulated in skin psoriatic lesions, inaganglionic and ganglionic areas of the colon in patients with Hirschsprung's disease, and inflamed mucosa of patients with inflammatory bowel disease (IBD).
IL-36 gamma is a pro-inflammatory factor. IL-36 gamma mediates inflammatory response through the activation of NF-κB and MAPK signaling pathway.
蛋白编号:Q9NZH8 (S18-D169)
基因 ID:56300
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-36 | 白细胞介素-36γ
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-36 | IL-36 gamma
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