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MCE 国际站:Fas Ligand Protein, Rat (P.pastoris, His)
Fas Ligand (CD178;APTL) 是 TNFRSF6/FAS/CD95 的配体,转导凋亡信号以调节细胞毒性 T 细胞介导的凋亡,自然杀伤细胞介导的凋亡和 T 细胞发育。大鼠的 Fas Ligand 具有 4 种亚型,其中可溶形式 (127-278 a.a.) 参与了自身免疫性睾丸炎大鼠睾丸生殖细胞凋亡。重组大鼠 Fas 配体 (P.pastoris, His) 全长 175 个氨基酸 (L104-L278),由 P.pastoris 细胞表达,带有 N 端 His 标签。
Synonyms: Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6
Species: Rat
Source: P. pastoris
研究背景:Fas Ligand (FasL; FASLG; CD95L), is a ligand for TNFRSF6/FAS belonging to the tumor necrosis factor (TNF). FasL is a type II transmembrane protein, riggering apoptosis of lymphocytes.
FasL is expressed on a variety of cell types, including T cells, natural killer (NK) cells, monocytes, neutrophils, breast epithelial cells, and vascular endothelial cells.
FasL exerts different biological activity by cleaved into 4 isoforms including membrane form, soluble form, ADAM10-processed FasL form (APL) and SPPL2A-processed FasL form (SPA). Among them, the membrane-bound form and a soluble form generated by proteolytic action of matrix metalloproteinases (MMP).
FasL or soluble FasL binding to Fas results in receptor aggregation and in the interaction of a protein called Fas-associated death domain with the Fas cytoplasmic tail. The interaction triggers a cascade of intracellular events, including the activation of the IL-1-converting enzyme-like cysteine protease (caspase 8), that ultimately leads to nucleoprotein cleavage, DNA fragmentation, and cell apoptosis.
Fas-Fas Ligand system in rat is one of the main mediators of apoptosis in experimental autoimmune orchitis (EAO), involves in germ cell (GC) death induction.
The loss of function due to mutations in murine FasL, murine Fas, human Fas, or human FasL leads to lymphoproliferation, lymphadenopathy, and autoimmune diseases.
Meanwhile, defective activation-induced cell death (AICD) results in spontaneous mutation of Fas and FasL genes in mice with lupus-like autoimmune disease.
Human Fas Ligand also involves in Jurkat cell apoptosis and binds TNFRSF6B/DcR3 to bolck apoptosis, which is a decoy receptor of apoptosis termination.
FasL is widely found in different animals, while the sequence in Mouse is highly similar to Rat (91.37%), but very different from Human with similarity of 78.06%.
FasL is widely found in different animals, while the sequence in Rat is highly similar to Mouse (91.37%), but very different from Human with similarity of 77.26%.
蛋白编号:P36940 (L104-L278)
基因 ID:25385
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子配体 | Fas 配体 | CD 抗原 | T 细胞 CD 蛋白 | CD178/FasL | CD 抗原 | NK 细胞 CD 蛋白 | CD178/FasL | CD 抗原 | 上皮细胞 CD 蛋白 | CD178/FasL | CD 抗原 | 内皮细胞 CD 蛋白 | CD178/FasL
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Superfamily Ligands | Fas Ligand (FasL) | CD Antigens | T Cell CD Proteins | CD178/FasL | CD Antigens | NK Cell CD Proteins | CD178/FasL | CD Antigens | Epithelial cell CD Proteins | CD178/FasL | CD Antigens | Endothelial cell CD Proteins | CD178/FasL
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