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MCE 国际站:IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi)
IL-17F 是一种炎性同型二聚体细胞因子,可诱导许多促炎细胞因子和趋化因子。IL-17F 也能诱导抗菌肽。IL-17F 在结肠癌发展中起保护作用,可用于自身免疫性疾病、感染和癌症的研究。IL-17F Protein, Mouse (Biotinylated, HEK293, His-Avi) 是一种生物素化的重组小鼠 IL-17F 蛋白,在 HEK293 细胞中表达,C 端带有 His 和Avi 标签,由 133 个氨基酸组成 (R29-A161)。
Synonyms: Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1
Species: Mouse
Source: HEK293
Biological Activity: Immobilized Mouse IL-17RA , hFc Tag at 1μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Mouse IL-17F, His Tag with the EC50 of 2.9μg/ml determined by ELISA.
研究背景:Interleukin-17F (IL-17F) belongs to the IL-17 cytokine family. IL-17F is expressed in activated CD4 T cells, activated monocytes, basophils and mast cells. IL-17F can be produced by differentiated TH17 cells, lamina propria T cells, memory CD4+ T cells, γδ T cells and NKT cells.
The mouse IL-17F shares 55.90% amino acid sequence identity with human and 86.34% identity with rat.
IL-17F is an inflammatory cytokine that induces many proinflammatory cytokines and chemokines, including TGF-β, IL-2, ICAM1, GM-CSF, CCL2, CCL7, TSLP, MMP13, IL-6 and CXCL1. IL-17F also induces antimicrobial peptides including hBD-2, S100A7, S100A8 and S100A9 with IL-22 and can synergize with IL-23 in human eosinophils to promote the production of IL-1β and IL-6. IL-17F is a homodimeric cytokine. IL-17F shares the most similarities with IL-17A (50% homology) and can be produced as an IL-17AF heterodimer. IL-17A, IL-17F and IL-17A/F use the same receptor complex: IL-17RA and IL-17RC heterodimer. They trigger qualitatively similar signaling pathways, and IL-17F exhibits the lowest biological activity. IL-17F shows about 100–1000 times lower affinity to the IL-17RA subunit than IL-17A, and does not compete with IL-17A binding to IL-17RA.
IL-17F plays a protective role in colon cancer development and can be used for the research of autoimmune diseases, infection and cancer.
蛋白编号:Q7TNI7 (R29-A161)
基因 ID:257630
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-17 | 白细胞介素-17F | 生物素标记蛋白
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-17 | IL-17F | Biotinylated Proteins
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