MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:BMPR1A/ALK-3 Protein, Mouse (152a.a, HEK293, His-Fc)
BMPR1A/ALK-3 蛋白 (ACVRLK3) 是骨形态发生蛋白 I 型受体,在组织中广泛表达。BMPR1A/ALK-3 蛋白介导铁代谢因子 hepcidin 表达,与 GDF5/6 相互作用调节软骨细胞分化和脂肪形成。BMPR1A-ID2/ZEB1-TGFBR2 信号可能是肺动脉高压 (PAH) 和其他内皮间质转换 (EndoMT) 相关血管疾病的潜在靶点。人的 BMPR1A/ALK-3 蛋白全长 532 个氨基酸,具有一个特异识别 BMP 配体的基序 (107-109 a.a.)。重组小鼠 BMPR1A/ALK-3 蛋白 (152a.a, HEK293, His-Fc) 由 HEK293 细胞表达,全长 152 个氨基酸 (M1-R152),带有 C 端 Fc 和 His 标签。
Synonyms: ALK-3; BMPRIA; Bone morphogenetic protein receptor type-1A; SKR5; CD292
Species: Mouse
Source: HEK293
研究背景:ALK-3 (BMPR1A; ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, for BMP2, BMP4, GDF5 and GDF6. Among BMP type I receptors, ALK-2 and 3 are widely expressedin tissues, while ALK-1 is more selectively expressed in endothelial cells (ECs). Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. BMP/ALK/SMAD pathway controls hepcidin expression, while BMP type I receptors ALK-2 and ALK-3 are responsible for iron-dependent hepcidin upregulation and basal hepcidin expression, respectively, to avoid low hepcidin which causes iron overload or high hepcidin levels which induce iron-restricted erythropoiesis. ALK-3 positively regulates chondrocyte differentiation through GDF5 interaction and mediates induction of adipogenesis by GDF6. ALK-3 protein shows function for the initiation of chondrogenesis, for regulating differentiation along the chondrogenic lineage, and for endochondral bone formation. Components of BMP signaling have been implicated in both pathogenesis of pulmonary arterial hypertension (PAH) and endothelial-mesenchymal transition (EndoMT), and BMPR1A is key to maintain endothelial identity and to prevent excessive EndoMT. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potential novel target for PAH and other EndoMT-related vascular disorders.
蛋白编号:P36895 (M1-R152)
基因 ID:12166
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 骨形态发生蛋白受体 | 骨形态发生蛋白 1A 型受体 | CD 抗原 | 上皮细胞 CD 蛋白 | ALK-3/CD292 | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 骨形态发生蛋白 1A 型受体 | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 骨形态发生蛋白 1A 型受体
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | BMP Receptor | ALK-3 | CD Antigens | Epithelial cell CD Proteins | ALK-3/CD292 | Receptor Proteins | Receptor Serine/Threonine Kinases | ALK-3 | Enzymes & Regulators | Serine/Threonine Kinase Proteins | ALK-3
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。