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MCE 国际站:ALK-1 Protein, Human (HEK293, Fc)
ALK-1,也称为 ACVRL1,是TGF-β 超家族的 I 型受体,具有 2 个配体 BMP9 和BMP10。ALK-1 主要在内皮细胞中表达,在调节发育和病理性血管生成中起关键作用。ALK-1 Protein, Human (97a.a, HEK293, Fc) 在 HEK293 细胞中产生,由 97 个氨基酸 (D22-Q118) 组成,在 C 末端带有Fc 标签。
Synonyms: rHuActivin Receptor-like Kinase 1, C-Fc; ALK-1; ACVRL1; Activin Receptor-like Kinase 1
Species: Human
Source: HEK293
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景:ALK-1, also known as ACVRL1, is a type I receptor for TGF-β superfamily with 2 ligands, BMP9 and BMP10. ALK-1 is predominantly expressed in endothelial cells and plays a critical role in regulating angiogenesis.
Mature human ALK-1 shares 89% amino acid sequence identity with mouse and rat ALK-1. While, mouse ALK-1 shares 96% aa sequence identity with rat ALK-1 protein.
ALK-1 is able to bind to TGF-β1 or activins in the presence of either TβR-II or activin type II receptors, respectively. However, ALK-1 does not elicit a specific transcriptional response. Thus, ALK-1 has been considered an “orphan” receptor. ALK-1 is a type I receptor that mediates signaling of BMP9 (bone morphogenetic protein) and BMP10, proteins in the TGF-β superfamily. Signaling through ALK-1 results in phosphorylation of the intracellular Smad 1/5/8 cascade which activates proangiogenic transcription factors such as ID1 and ID3. ALK-1 binds to TGF-β1 and phosphorylates Smad1 and Smad5. Overexpression of ALK-1 in HepG2 cells inhibits the ALK5-mediated TGF-β1 response. The balance between ALK-1 and ALK5 may be crucial for controlling the properties of endothelium during angiogenesis. BMP9/BMP10/ALK-1 signaling controlled the specific gene expression program and survival of Kupffer cells (KCs) through a Smad4-dependent pathway. Functionally, the loss of ALK-1 resulted in impaired capture of L. monocytogenes and overwhelming disseminated infections.
ALK-1 is expressed in blood vessels during embryogenesis and adult stages. In addition, mutations of the ALK-1 gene have been linked to the type II hereditary hemorrhagic telangiectasia. ALK-1 inhibits BMP9-mediated Id-1 expression in human umbilical vein endothelial cells. In a chick chorioallantoic membrane assay, ALK-1 reduces VEGF-, FGF-, and BMP10-mediated vessel formation. In addition, ALK1 reduces tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.
蛋白编号:P37023 (D22-Q118)
基因 ID:94
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | Activin/Inhibins Receptor | 激活素受体样激酶 1 | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 激活素受体样激酶 1 | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 激活素受体样激酶 1
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins Receptor | ALK-1/ACVRL1 | Receptor Proteins | Receptor Serine/Threonine Kinases | ALK-1/ACVRL1 | Enzymes & Regulators | Serine/Threonine Kinase Proteins | ALK-1/ACVRL1
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