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MCP-2/CCL8 Protein, Mouse

MCE 国际站：MCP-2/CCL8 Protein, Mouse

MCP-2/CCL8 Protein, Mouse 是一种 CC 趋化因子，可以与  CCR1、CCR2B、CCR3 和 CCR5 相互作用，介导宿主炎症免疫反应、肿瘤发生以及抗病毒感染。MCP-2/CCL8 Protein, Mouse 是一种由 E. coli 表达的重组小鼠 MCP-2/CCL8 (G24-P97) 蛋白。

Synonyms: rMuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8

Species: Mouse

Source: E. coli

Biological Activity: 1. Full biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.
2. Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED₅₀ this effect is 0.05265 μg/mL, corresponding to a specific activity is 1.899×10^4 U/mg.

研究背景：CCL8, also known as monocyte chemotactic protein 2 ( MCP2), is a small cell factor belonging to the CC chemokine family. First identified in human osteosarcoma cells, it is a protein encoded by the CCL8 gene located on human chromosome 17. CCL8 is mainly expressed in small intestine and peripheral blood cells. CCL8 can bind to several different chemokine cell surface receptors, such as CCR1, CCR2B, CCR3 and CCR5. CCL8 can act as a chemoattractant, attracting chemokines such as monocytes, lymphocytes, basophils and eosinophils to mediate inflammatory host responses. On the one hand, CCL8 contributes to the spread of breast cancer and promotes the migration and invasion of esophageal squamous cell carcinoma. On the other hand, it has also been reported that CCL8 inhibits cervical cancer tumor growth and exhibits anti-tumor metastatic effects in melanoma. cCL8 significantly activates ERK1/2 phosphorylation in glioblastoma cells and significantly reduces the invasiveness of glioma cells by neutralizing antibody blockade of tama-secreted CCL8. At the same time, CCL8 can act as a potent HIV1 inhibitor with high affinity for the receptor CCR5, which is one of the major co-receptors for HIV1.

蛋白编号：Q9Z121 (G24-P97)

基因 ID：20307

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL8

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  MCP-2 Protein/CCL8

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