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MCE 国际站:ACVR2B Protein, Human (HEK293, Fc)
ACVR2B 是受体丝氨酸/苏氨酸激酶TGF-β 家族的 II 型成员。ACVR2B 与激活素和生长分化因子 (GDF) 结合,进而激活 I 型受体,从而激活下游分子 SMAD2/3。ACVR2B Protein, Human (HEK293, Fc) 在 HEK293 细胞中产生,由 134 个氨基酸(M1-T134) 组成,在 C 末端带有 Fc 标签。
Synonyms: Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B
Species: Human
Source: HEK293
Biological Activity: Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is 0.1292 µg/mL in the presence of 10 ng/mL recombinant Activin A, corresponding to a specific activity is 7.097×10^3 units/mg.
研究背景:Activin receptor type-2B (ACVR2B), also known as ActR-IIB and MGC116908, is an activin type II receptor. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors.
The sequence of amino acids in ACVR2B proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ACVR2B has been only slightly altered, and that both in humans and in animals, its function is similar.
Activins and growth differentiation factors (GDF) bind to ACVR2B, which in turn activate type I receptors such as activin receptor-like kinases (ALK) ALK4 and ALK5, activating downstream molecule SMAD2/3. SMADSs regulate a number of myogenic genes, such as myoD, myogenin, and Myf5, that are involved in cellular hypertrophy, proliferation, or differentiation. Noncanonical ACVR2B pathways have also been shown to regulate MAP kinases. ACVR2B blocks signaling of myostatin, its close homolog GDF11, as well as activin A, activin B, and BMP10. Activin A primarily binds to the type 1 receptors ALK4 or ALK7 in complex with ACVR2A or ACVR2B, causing activation of SMAD2 or SMAD3.
In myeloma cells, BMP-6- and BMP-9-induced activation of SMAD1/5/8 through ACVR2A/ACVR2B/ALK2 is inhibited by activin A treatment. ACVR2B has been shown to preserve muscle mass and prolong survival in tumor hosts, and to increase bone mass in models of osteogenesis imperfecta and muscular dystrophy.
蛋白编号:NP_001097.2 (S19-T134)
基因 ID:93
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | Activin/Inhibins Receptor | 激活素受体 Ⅱb | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 激活素受体 Ⅱb | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 激活素受体 Ⅱb
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins Receptor | Activin A Receptor Type 2B (ACVR2B) | Receptor Proteins | Receptor Serine/Threonine Kinases | Activin A Receptor Type 2B (ACVR2B) | Enzymes & Regulators | Serine/Threonine Kinase Proteins | Activin A Receptor Type 2B (ACVR2B)
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