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Alogliptin Benzoate

CAS No. : 850649-62-6

MCE 国际站：Alogliptin Benzoate

产品活性：Alogliptin Benzoate (SYR-322) 是一种有效的、具有选择性口服活性的 DPP-4 的抑制剂，IC₅₀ 值小于 10 nM，比对 DPP-8 和 DPP-9 的抑制性高 10000 倍以上。Alogliptin Benzoate 可用于研究 2 型糖尿病。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Dipeptidyl Peptidase  |  Ferroptosis

In Vitro: Alogliptin (1 nM; 5-60 min) inhibits LPS-induced extracellular signal-regulated kinase (ERK) phosphorylation in U937 cells.
Alogliptin (0.5-5 nM; 24 h) inhibits LPS-stimulated MMP-1 secretion and mRNA expression that is mediated by ERK pathway in U937 cells.

In Vivo: Alogliptin (0.01-1 mg/kg; p.o.) produced dose-dependent improvements in glucose tolerance and increased plasma insulin levels in female Wistar fatty rats.
Alogliptin (40 mg/kg/day for 2 weeks; p.o.) reduces infarction area and improves brain vascular integrity in middle cerebral artery occlusion (MCAO) mice.

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