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LIF Protein, Mouse

MCE 国际站：LIF Protein, Mouse

LIF Protein, Mouse是参与各种神经和炎症过程的淋巴因子，例如急性期反应，组织损伤和感染。

Synonyms: rMuLIF; Differentiation-stimulating Factor; D factor; MLPLI

Species: Mouse

Source: E. coli

Biological Activity: The ED₅₀ is <0.01 ng/mL as measured by M1 cells, corresponding to a specific activity of >1.0 × 10⁸ units/mg.

研究背景：Leukemia Inhibitory Factor (LIF) has been shown to possess a remarkable variety of actions. It releases calcium from bone tissue, and is the differentiation inhibitory factor preventing spontaneous differentiation in normal embryonic stem cells. Leukemia inhibitory factor (LIF) is involved in both the neural and immune responses to injury. Its levels are increased in a variety of animal and human inflammatory conditions. Administration of Leukemia Inhibitory Factor can suppress inflammatory signs in some cases, for instance after intratracheal lipopolysaccharide-induced inflammation. Leukemia Inhibitory Factor also increases corticosterone levels via the hypothalamo-pituitary-adrenal axis. Exogenously added Leukemia Inhibitory Factor induces acute phase protein expression and stimulates the production of proinflammatory cytokines and monocyte chemoattractants. In the hematopoietic system, LIF induces the differentiation of certain leukemic cells and the proliferation of hematopoietic stem cells, megakaryocyte progenitor cells and DA1 cells. LIF also has activity in bone remodelling, induction of the acute phase response in hepatocytes, inhibition of adipogenesis, regulation of nerve differentiation and inhibition of kidney epithelial cell differentiation.

蛋白编号：P09056 (S24-F203)

基因 ID：16878

产品分类：细胞因子和生长因子  |  神经营养因子  |  白血病抑制因子

Categories：Cytokines and Growth Factors  |  Neurotrophic Factors  |  Leukemia Inhibitory Factor

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