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Beta-NGF Protein, Human (HEK293)

MCE 国际站：Beta-NGF Protein, Human (HEK293)

神经生长因子 (NGF) 是调节神经元存活和分化的神经营养因子，也是一种精浆蛋白，参与促排卵和促黄体作用。NGF 在女性生殖系统中具有潜在功能，有助于克服当前早期胚胎丢失的问题。 重组人 Beta-NGF 蛋白 (HEK293) ，是由 HEK293 细胞产生的重组蛋白 (S122-R239)，不带标签。

Synonyms: rHuBeta-NGF; Beta-Nerve Growth Factor; Beta-NGF;

Species: Human

Source: HEK293

Biological Activity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 0.04-0.4 ng/mL.

研究背景：Nerve Growth Factor-β (Beta-NGF; NGF) is a basic protein of 118 amino acids which acts are a trophic factor for sensory and sympathetic neurons of the peripheral nervous system, and on cholinergic neurons of the anterior basal cerebrum. NGF involves in the regulation of neuronal survival and differentiation. Elevated levels of NGF are associated with the risk of post-traumatic stress disorder (PTSD). The trauma response leads to methylation of DNA nucleotides responsible for NGF expression. NGF levels have shown increased sympathetic fiber density proportional to NGF messenger RNA (mRNA) levels. NGF is also a seminal plasma protein commonly found in mammals. For example, NGF acts as an ovulation stimulating factor in camels and has been shown to have luteinizing effects in bulls. NGF has a potential function in the female reproductive system. For example, NGF plays an important role in ovulation induction, LH release, ovulation, luteal development, progesterone (P4) production, vascularization of luteal body, and gonadotropin response. Application of NGF to cattle enhances steroid production, luteal formation and function by increasing LH release, and leads to increased mRNA expression of markers of pregnancy and development downstream. In addition, the potential luteinizing effect of NGF could help overcome the current problem of early embryo loss. The similarity between human and bovine NGF protein sequence was 90.87%. Meanwhile, the similarity rate of human NGF with rat and mouse was 85.89% and 85.06%, respectively.

蛋白编号：P01138 (S122-R239)

基因 ID：4803

产品分类：细胞因子和生长因子  |  神经营养因子  |  神经营养素  |  神经生长因子

Categories：Cytokines and Growth Factors  |  Neurotrophic Factors  |  Neurotrophins/NGF  |  Nerve Growth Factor-β (Beta-NGF)

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