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Artemisinin

CAS No. : 63968-64-9

MCE 国际站：Artemisinin

产品活性：Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，从黄花蒿 (Artemisia annua L.) 植物的地上部分分离的抗疟疾活性分子。Artemisinin 以剂量依赖性方式降低 pAKT 来抑制 AKT 信号通路。Artemisinin 可减少癌细胞的增殖，迁移，侵袭，肿瘤发生和转移，同时 Artemisinin 有神经保护作用。

研究领域：Anti-infection  |  PI3K/Akt/mTOR  |  Apoptosis

作用靶点：HCV  |  Parasite  |  Akt  |  Ferroptosis

结构分类：萜类  |  倍半萜  |  结构分类

来源：植物  |  豆科  |  毒鱼豆  |  植物  |  菊科

In Vitro: Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells.
Artemisinin (1-100 μM; 24 hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC₅₀ values of 31.30 ± 0.73 μM in UMRC-2 cells and 23.97 ± 0.92 CAKI-2 cells.
Artemisinin (25, 50 μM; 24 hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner.

In Vivo: Artemisinin (gavage; 20 mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth.

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