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CAS No. : 66584-72-3
MCE 国际站:Ansamitocin P-3
产品活性:Ansamitocin P-3 (Antibiotic C 15003P3) 是一种微管 (microtubule)抑制剂。Ansamitocin P-3 是一种大环抗肿瘤抗生素。
研究领域:Cell Cycle/DNA Damage | Cytoskeleton | Antibody-drug Conjugate/ADC Related | Anti-infection
作用靶点:Microtubule/Tubulin | ADC Cytotoxin | Bacterial | Antibiotic
结构分类:抗生素 | 疾病研究 | 抗癌 | 抗生素 | 其他类 | 结构分类
In Vitro: Ansamitocin P-3 (Antibiotic C 15003P3) potently inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture with a half-maximal inhibitory concentration of 20±3, 50±0.5, 140±17, and 150±1.1 pM, respectively. Further, Ansamitocin P3 is found to bind to purified tubulin in vitro with a dissociation constant (Kd) of 1.3±0.7 μM. The binding of Ansamitocin P3 induces conformational changes in tubulin. Ansamitocin P3 inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture in a concentration dependent manner. Flow cytometric analysis of PI-stained cells suggests that Ansamitocin P3 inhibits the cell cycle progression of MCF-7 cells in G2/M phase. For example, 26, 50 and 70% of the cells are found to be in G2/M phase in the absence and presence of 50 and 100 pM Ansamitocin P3, respectively.
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货号: HY-15739
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