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MCE 国际站:IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc)
IL-2R beta (CD122) 和 IL-2Rγ (CD132),一种表达于 T 淋巴细胞上的 Ⅰ 型细胞因子受体,都是 IL-2 的受体。IL-2R beta 可介导 T 细胞免疫反应,IL-2Rγ 介导炎症反应。IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc) 是一种由 HEK293 细胞产生的重组人 IL-2R beta (A27-D239) & IL-2R gamma (L23-A262) 异二聚体,其 C 末端带有 hFc 标签。
Synonyms: IL-2RB&IL-2RG; IL-2RG; IL-2R subunit gamma; IL-2R subunit beta; IL-2RB; IL15RB; IL-2 R beta&IL-2 R gamma
Species: Human
Source: HEK293
Biological Activity: Immobilized Human IL-15RA&IL-15, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human IL-2 R beta&IL-2 R gamma, hFc Tag with the EC50 of 72.0ng/ml determined by ELISA.
研究背景:IL-2R beta and IL-2R gama are both type I cytokine receptors, and belongs to Type 4 subfamily.IL-2R beta/gama heterodimer has intermediate affinity for IL-2. IL-2R beta/gama heterodimer complex transduces a signal when IL-2 concentrations are relatively high.
IL-2R beta is a key component of the IL-15 receptor. IL-2R beta is broadly expressed in spleen, blood, and lymph node, such as B and T lymphocytes.IL-2R gama is expressed in leucocyte subsets. IL-2R gama is involved in inflammatory response, and mediates activation of the cells
IL-2R beta cytoplasmic domain heterodimerizes with IL-2 and leads to the activation of signaling pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAP kinase, and the JAK-STAT pathways. IL-2R beta binds IL-2 with intermediate affinity. IL-2R beta mediates IL-2 internalization and signal transduction, such as cell proliferation or differentiation. IL-2R beta interacts with IL-2 and increases the proportion of CD4+ T lymphocytes. IL-2R stimulates T cell proliferation and activating lymphokine-activated killer cells.
IL-2R beta mediates T cell immune responses, and also mediates endocytosis, as well as transducing the mitogenic signals of IL-2.
蛋白编号:P14784 (A27-T240)&P31785 (L23-A262)
基因 ID:3560&3561
产品分类:细胞因子和生长因子 | 白细胞介素 | 白介素-2 受体 | 白介素-2 受体 beta | 细胞因子和生长因子 | 白细胞介素 | 白介素-2 受体 | 白介素-2 受体 gamma | CD 抗原 | NK 细胞 CD 蛋白 | CD122/IL-2R beta
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-2 Receptor | IL-2R beta | Cytokines and Growth Factors | Interleukin & Receptors | IL-2 Receptor | IL-2R gamma/Common gamma-Chain | CD Antigens | NK Cell CD Proteins | CD122/IL-2R beta
货号: HY-P77715
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