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CAS No. :
MCE 国际站:Lonodelestat TFA
产品活性:Lonodelestat TFA (POL6014 TFA) 是有效的、具有口服活性的、选择性的人中性粒细胞弹性蛋白酶(hNE) 的肽类抑制剂。Lonodelestat TFA 具有囊性纤维化 (CF) 研究的潜力 .
研究领域:Metabolic Enzyme/Protease
作用靶点:Elastase
In Vivo: Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice.
Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001).
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货号: HY-P3293A
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