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MCE 国际站:OX40/TNFRSF4 Protein, Human (HEK293, Fc)
OX40 (TNFRSF4) 是 OX40 配体的受体。OX40 常在 T 细胞上表达。OX40 Ligand 可以激活 OX40,从而扮演 T 细胞共刺激分子的角色。OX40-OX40 Ligand 之间的相互作用可促进效应 T 细胞存活并有效地诱导记忆 T 细胞生成,以及增强 Tfh 细胞对 B 细胞的辅助功能、促进 DCs 的分化和成熟。OX40/TNFRSF4 Protein, Human (HEK293, Fc) 是一种由 HEK293 产生的重组人 OX40 (L29-A216),C 端带 Fc 标签。
Synonyms: Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; TNFRSF4; OX40; CD134; Txgp1
Species: Human
Source: HEK293
研究背景:OX40 (TNFRSF4), a member of TNFR superfamily, is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells, but also found in natural killer T cells, natural killer cells, neutrophils, and human airway smooth muscle cells. Human OX40 shares <30% aa sequence identity with mouse and rat. Mouse OX40 shares 90% aa sequence identity with rat.
OX40 Ligand can activate OX40 and thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs.
The interaction between OX40 Ligand with OX40 is essential for the generation of antigen-specific memory T cells, and induces host antitumor immunity. But the over-upregulation of OX40 and OX40L may induce abnormal activation of Tfh cells and excessive production of autoantibodies, which leads to autoimmune disease.
蛋白编号:P43489 (L29-A216)
基因 ID:7293
产品分类:细胞因子和生长因子 | 肿瘤坏死因子超家族 | 肿瘤坏死因子受体 | OX40 | CD 抗原 | T 细胞 CD 蛋白 | CD134/OX40 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD134/OX40 | 免疫检查点蛋白 | 刺激性免疫检查点
Categories:Cytokines and Growth Factors | TNF Superfamily | TNF Receptor Superfamily | OX40 | CD Antigens | T Cell CD Proteins | CD134/OX40 | CD Antigens | Macrophage CD Proteins | CD134/OX40 | Immune Checkpoint Proteins | Stimulatory Immune Checkpoint Molecules
货号: HY-P70813
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