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MCE 国际站:TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293)
转化生长因子-β2 (TGF-β2) 是一种细胞外糖基化蛋白,是 TGF-β 超家族的成员。TGFβ2 通过I 型和 II 型受体 (TGFβR1 和 TGFβR2) 的信号传导控制关键的生理过程,包括细胞迁移、增殖和分化。TGF-β2 是一种免疫抑制因子,参与免疫耐受的发展,也调节胚胎发育。TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293) 在 HEK293 细胞中表达产生,由 112 个氨基酸(A303-S414) 组成。
Synonyms: TGFB2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; Polyergin; TGF-beta2; TGF-beta-2; transforming growth factor beta-2
Species: Rat;Mouse
Source: HEK293
Biological Activity: Immobilized Mouse TGFBR2 -Fc at 10μg/ml (100 μl/well) can bind Mouse/Rat TGF-beta 2*: Biotinylated by NHS-biotin prior to testing.The ED50 of Mouse TGFBR2 -Fc is 4.67 μg/mL.
研究背景:In mammals, three different isoforms of TGF-β are described (TGF-β1, TGF-β2 and TGF-β3; transforming growth factor beta) to regulate apoptosis, proliferation, differentiation, migration and invasion processes utilising overlapping but not redundant mechanisms. All three isoforms are expressed in the liver, but their expression is differentially distributed among liver cell types. TGF-β2 expression in different liver cell types and is also associated with developmental defects and fibrotic diseases in mice.
The sequence of amino acids in TGF-β2 proteins from different species is very stable, which leads to the conclusion that in the process of evolution, TGF-β2 has been only slightly altered, and that both in humans and in animals, its function is similar.
TGFβ2 is a transforming growth factor beta (TGFB) family cytokine, with members of this cytokine family playing broad regulatory roles and controlling key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2), with signals propagating via the downstream regulatory SMAD proteins. This TGFβ/SMAD pathway is frequently dysregulated in human cancer. TGFβ cytokines are capable of suppressing T cell growth in response to IL‐2. The degree of TGFβ2 expression correlated with the expression of several different markers of immune cell subsets within tumours. In addition, TGF-β2 regulates embryonic development and, therefore not surprisingly, global Tgfb2 null mice exhibit a wide range of developmental defects and perinatal mortality.
TGF-β2 is an immune suppressor involved in the development of immune tolerance, and recombinant TGF-β2 incubation is more potent than TGF-β1 or TGF-β3 in suppressing macrophage inflammatory responses. TGF-β2 is shown to correlate with bad prognosis in intrahepatic CCAs and hepatocellular carcinoma. Mechanistically, canonical Smad signalling as well as crosstalk with Yap, Hippo, Wnt and β-catenin signalling have been demonstrated in the liver and other organs.
蛋白编号:P27090 (A303-S414)
基因 ID:21808
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 转化生长因子β | 转化生长因子-β2 | 细胞因子和生长因子 | 神经营养因子 | 转化生长因子-β | 转化生长因子-β2
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Transforming Growth Factor-β | TGF-β2 | Cytokines and Growth Factors | Neurotrophic Factors | TGF- β | TGF-β2
货号: HY-P70649
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