MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:CTLA-4 Protein, Mouse (125a.a, HEK293, His)
CTLA-4 Protein, Mouse (125a.a, HEK 293, His) 是带有 His 标签的重组 CTLA-4 蛋白。CTLA-4 蛋白是一种单通道 I 型膜蛋白,属于 CD28 受体家族。CTLA-4 是一种阴性免疫调节剂,在 Treg 细胞上组成表达。
Synonyms: Ctla4; Cd152; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD antigen CD152
Species: Mouse
Source: HEK293
Biological Activity: The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 20 ng/mL.
研究背景:CTLA-4 and CD28 both belongs to a family of immunoglobulin-related receptors that are responsible for various aspects of T-cell immune regulation. CTLA-4 and CD28 are homologous receptors expressed by both CD4+ and CD8+ T cells, which mediate opposing functions in T cell activation.CTLA-4 interacts with both ligands (CD80 and CD86) with high affinity.CTLA-4 is a negative immune regulator constitutively expressed on Treg cells and upregulated on activated T cells. CTLA-4 inhibits T cell activation by various suppressive functions including competition with CD28, regulation of the inhibitory function of Treg cells, such as transendocytosis, and the control of adhesion and motility.
蛋白编号:P09793 (A37-D161)
基因 ID:12477
产品分类:免疫检查点蛋白 | 抑制性免疫检查点 | CTLA-4 | CD 抗原 | T 细胞 CD 蛋白 | CD152/CTLA-4 | CD 抗原 | 巨噬细胞 CD 蛋白 | CD152/CTLA-4 | CD 抗原 | 树突细胞 CD 蛋白 | CD152/CTLA-4
Categories:Immune Checkpoint Proteins | Inhibitory Checkpoint Molecules | CTLA-4 | CD Antigens | T Cell CD Proteins | CD152/CTLA-4 | CD Antigens | Macrophage CD Proteins | CD152/CTLA-4 | CD Antigens | Dendritic Cell CD Proteins | CD152/CTLA-4
货号: HY-P71991
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。