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MCE 国际站:IL-4 Protein, Mouse (CHO)
IL-4 Protein, Mouse (CHO)是一种 CHO 细胞来源的特异性细胞因子,促进 B 淋巴细胞的增殖,分化和细胞表面蛋白调节。
Synonyms: rMuIL-4; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
Species: Mouse
Source: CHO
Biological Activity: The ED50 is <2 ng/mL as measured by murine HT-2 cells, corresponding to a specific activity of >5 × 105 units/mg.
研究背景:Mouse Interleukin 4 is a 20-kDa glycoprotein, synthesized by activated T lymphocytes and mast cells, which regulates the growth and/or differentiation of a broad spectrum of target cells of the immune system, including B and T lymphocytes, macrophages, and hematopoietic progenitor cells. Murine Interleukin 4 (IL-4) is a potent mediator of an immune response, affecting both the growth and differentiation of a wide variety of cells in the hematopoietic lineage. This cytokine is expressed by activated T lymphocytes and mast cells as a 20-kDa glycoprotein. The cDNA for IL-4 isinitially is solated by two laboratories, using expression vectors and screening for either a IgG-inducing factor or a mast cell growth factor. The derived amino acid sequence from the cDNA clones is used to predict a protein backbone for IL-4 of 14 kDa. This is consistent with the observation that N-glycanase treatment of natural IL-4, to remove N-linked carbohydrates, yields a protein core of 14 kDa. Initial experiments with deglycosylated native IL-4 and with deglycosylated recombinant IL-4, expressed initially in yeast as a heterogeneous, hyperglycosylated molecule, suggested that the carbohydrate modifications of IL-4 do not affect its ability to bind to receptor and to stimulate T and B cell growth.
蛋白编号:P07750 (H21-S140)
基因 ID:16189
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-4
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-4
货号: HY-P7080
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