MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Lys05

CAS No. : 1391426-24-6

MCE 国际站：Lys05

产品活性：Lys05 (Lys01 trihydrochloride) 是新颖的溶酶体自噬 (lysosomal autophagy) 抑制剂。在MTT试验中，对1205Lu, c8161, LN229 和HT-29细胞系的IC₅₀值分别为3.6, 3.8, 6 和7.9 μM。

研究领域：Autophagy

作用靶点：Autophagy

In Vitro: Lys01, is a 10-fold more potent autophagy inhibitor than HCQ. Compared with HCQ, Lys05, a water-soluble salt of Lys01, more potently accumulates within and deacidifies the lysosome. Lys01 and Lys05 produce equivalent dose-dependent increases in the LC3II/LC3I ratio, accumulation of the autophagy cargo protein p62, and identical IC₅₀ values in the MTT assay.

In Vivo: With this high-dose, short-term treatment, no mice die, but after 2 d of dosing, mice treated with Lys05 76 mg/kg i.p. are observed to have arched backs and lethargy. Morphologically, EM show that cells with intact nuclear and cytoplasmic membranes contain large AVs in Lys05-treated tumors. Tumor growth is significantly impaired in Lys05-treated tumors compared with controls. Lys05 treatment results in a 53% reduction in the average daily tumor growth rate compared with vehicle-treated controls. A significant three- and six-fold accumulation of AV is observed at the end of 14 d of treatment in HCQ- and Lys05-treated tumors, respectively, compared with control-treated tumors.

相关产品：Bioactive Compound Library Plus  |  Anti-Cancer Compound Library  |  Autophagy Compound Library  |  Heterocyclic Compound Library  |  Pepstatin Ammonium  |  Meloxicam-d₃-1  |  Sorafenib-d₄  |  Carboplatin-d₄  |  Lapatinib ditosylate  |  AT9283  |  Erlotinib-d₆ hydrochloride  |  Ranolazine-d₈ dihydrochloride  |  6-Mercaptopurine-¹³C₂,¹⁵N  |  BIX-01294  |  Dinoprost-d₄  |  Curcumin  |  XRK3F2  |  Cysteamine-d₄ hydrochloride  |  Colistin sulfate  |  Salvianolic acid B  |  Aloperine  |  Topotecan hydrochloride hydrate  |  10074-G5  |  Tazarotene-d₈  |  Chenodeoxycholic acid-d₅  |  Carbamazepine-d₂  |  WYE-354  |  Retinoic acid  |  DBeQ  |  Flavopiridol  |  Trifluoperazine dihydrochloride  |  Salicylic acid-¹³C₆  |  Antitumor agent-97  |  Erlotinib Hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-12855A

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。