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CAS No. : 213819-48-8
MCE 国际站:Belotecan hydrochloride
产品活性:Belotecan hydrochloride (CKD-602 hydrochloride) 是拓扑异构酶 I (Topoisomerase I) 抑制剂,是一种合成的喜树碱衍生物。
研究领域:Cell Cycle/DNA Damage
作用靶点:Topoisomerase
In Vitro: Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
In Vivo: Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Lung Cancer Compound Library | FDA-Approved Anticancer Drug Library | Heterocyclic Compound Library | Off-patent Drug Library | Gepotidacin | Topoisomerase IV inhibitor 2 | Phenoxodiol | Topotecan hydrochloride hydrate | NHC-triphosphate tetraammonium | Berberine | Levofloxacin sodium | TAS-103 dihydrochloride | Ciprofloxacin | Mitoxantrone diacetate | Murrayanol | Gimatecan | Camptothecin | EGFR-IN-57 | SW044248 | Topoisomerase I/II inhibitor 4 | NHC-diphosphate triammonium | Betulinic acid | ICRF-196 | 3,6-Diamino-9(10H)-acridone | Epirubicin | 12-Ethyl-9-hydroxycamptothecin | Topoisomerase II inhibitor 3 | Becatecarin | Pixantrone hydrochloride | Datopotamab deruxtecan | Isosteviol
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-13566A
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