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CAS No. : 1913269-12-1
MCE 国际站:KN-93 phosphate
产品活性:KN-93是钙离子/钙调蛋白依赖激酶II(CaMKII)抑制剂,能竞争性阻断钙调蛋白与对应激酶的结合,Ki为370 nM。
研究领域:Neuronal Signaling | Autophagy
作用靶点:CaMK | Autophagy
In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93.
相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | Neuronal Signaling Compound Library | Anti-Cancer Compound Library | Autophagy Compound Library | Autocamtide-3 | Trifluoperazine dihydrochloride | Calmodulin-Dependent Protein Kinase II(290-309) acetate | Cabamiquine | TX-1123 | Autocamtide-2-related inhibitory peptide, myristoylated TFA | CS587 | CaMKII-IN-1 | TIM-063 | KN-62 | A-484954 | Ph-HTBA | Autocamtide 2, amide | K-252a | Sordarin sodium | Calmidazolium chloride | MLCK inhibitor peptide 18 | Syntide 2 TFA | Autocamtide-2-related inhibitory peptide | Trifluoperazine-d3 dihydrochloride | Rimacalib | Calmodulin Dependent Protein Kinase Substrate Analog | PROTAC eEF2K degrader-1
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货号: HY-15465B
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