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CAS No. : 17318-31-9
MCE 国际站:SQ22536
产品活性:SQ22536 是一种有效的腺苷酸环化酶 (AC) 抑制剂。
研究领域:GPCR/G Protein
作用靶点:Adenylate Cyclase
In Vitro: SQ22536 (SQ22,536) effectively inhibits the effect of forskolin with respective IC50 values of 5 μM.
Preincubation with graded concentrations of SQ22536 reveals that both SQ22536 effectively inhibits PACAP-induced reporter gene activation with approximate IC50 value of 5 μM.
SQ22536 more potently inhibits forskolin-induced Elk activation (IC50=10 μM) than 8-Br-cAMP-induced Elk activation (IC50=170 μM).
Most notably, there are substantial differences in the reported potencies of SQ22536 to inhibit the activities of recombinant AC5 and AC6, with respective IC50 values of 2 μM and 360 μM. At a greater concentration (500 μM), SQ22536 significantly inhibits neurite elongation due to either forskolin or 8-Br-cAMP.
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