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CAS No. : 3366-95-8
MCE 国际站:Secnidazole
产品活性:Secnidazole (RP-14539) 是一种唑类抗生素和黏质沙雷菌毒力的咪唑缓释剂,具有口服活性。Secnidazole 作为一种类似于酰基高丝氨酸内酯,能有效抑制 QS 导致铜绿假单胞菌的发病衰减。Secnidazole 在体外对多种厌氧革兰氏阴性和革兰氏阳性细菌均有抗菌活性。Secnidazole 可用于各种疾病的研究,如阿米巴病和贾第虫病,以及细菌性阴道炎。
研究领域:Anti-infection
作用靶点:Parasite | Antibiotic | Bacterial
In Vitro: Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively.
Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition.
Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2.
Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6.
Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL.
In Vivo: Secnidazole (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice.
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