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(R)-Morinidazole

CAS No. : 898230-59-6

MCE 国际站：(R)-Morinidazole

产品活性：(R)-Morinidazole 是一种口服有效的 5-硝基咪唑抗菌剂，在人体中通过 N⁺-葡萄糖醛酸化和磺化进行代谢。(R)-Morinidazole 可用于用于研究细菌感染，包括厌氧菌引起的阑尾炎、盆腔炎 (PID) 等。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: (R)-Morinidazole can be metabolized to N⁺-glucuronide of S-Morinidazole R enantiomer [M8-1] and N⁺-glucuronide of (R)-Morinidazole [M8-2] via N⁺-glucuronidation, and sulfate conjugate of (R)-Morinidazole [M7] via sulfation.
M7 is a substrate for organic anion transporter 1 (OAT1) and OAT3 (K_m=28.6 and 54.0 μM, respectively), M8-1 and M8-2 are the substrates for OAT3.
(R)-Morinidazole shows activity against Trichomonas vaginalis and Entamoeba histolytica in vitro, with MIC values of 2 μg/mL and 3 μg/mL, respectively.

In Vivo: (R)-Morinidazole (20 mg/kg or 25 mg/kg; p.o.; single dose) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo in rats with EC₅₀s of 20 mg/kg and 25 mg/kg, respectively.
(R)-Morinidazole (50 mg/kg; i.v.; 0.25, 0.75, 1.5 h) shows a different concentration in tissues after intravenous injection, with a higher concentration in liver, kidney, plasma than lung, heart, and spleen in mice.
Pharmacokinetic parameters of (R)-Morinidazole in control and 5/6 nephrectomized (Nx) rats

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