MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CU-115

CAS No. : 2471982-20-2

MCE 国际站：CU-115

产品活性：CU-115 是一种强有力的 TLR8 拮抗剂 (IC₅₀=1.04 µM)，并显示了对 TLR8 选择性高于TLR7 (IC₅₀=>50 µM)。CU-115 降低了由 R-848 激活的 THP-1 细胞 TNF-α 和 IL-1β 的产生。

研究领域：Immunology/Inflammation

作用靶点：Toll-like Receptor (TLR)

In Vitro: In endosomal and non-endosomal TLR specificity studies, Human embryonic kidney (HEK) 293 cells expressing human tolllike receptor (hTLR) gene and an inducible secreted embryonic alkaline phosphatase (SEAP) reporter gene were incubated with CU-115 for 16 hours. As a result, CU-115 displays activity for TLR7 and TLR8 at low concentrations (0.5 μM).
CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, Poly(I:C), LPS, R848, and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells. And CU-115 inhibits TLR9 signaling at 1, 5, and 20 µM and ~10-25% inhibition.
CU-115 (5-20 µM) inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay.
CU-115 (0.5, 1.0, 5, and 20 µM; 16 hours) is nontoxic at low concentrations (0.5 and 20 μM) and toxic at 100 μM in Hek293 TLR7 and TLR8 cells. CU-115 also is nontoxic at low concentrations (0.5 and 20 μM) and displays partial toxicity at 100 μM in THP Dual cells.
The enzyme-linked immunosorbent assay (ELISA) is performed to measure upregulation/inhibition of TNF-α in human THP-1 cells (hTHP-1). CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) in hTHP1. It also represses the expression of IL-1β in hTHP-1 cells. These results suggest that CU-115 suppresses TLR8 and TLR7 signaling pathways.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Small Molecule Immuno-Oncology Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Antidepressant Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Highly Selective Inhibitors Library  |  C29  |  ODN 1018  |  TLR7 agonist 5  |  AN-3485  |  ODN 2088  |  TLR4/NF-κB/MAPK-IN-1  |  TLR9-IN-1  |  Complete Freund's adjuvant (CFA)  |  ODN 105871  |  MC-Val-Cit-PAB-Amide-TLR7 agonist 4  |  Monophosphoryl lipid A  |  β-D-Glucan  |  Poly (I:C):Kanamycin (1:1) (sodium)  |  ODN TTAGGG  |  Bropirimine  |  Polygalasaponin F  |  Chloroquine-d₅ diphosphate  |  DB-3-291  |  ODN 24888  |  ODN 2216  |  Agatolimod  |  Enpatoran hydrochloride  |  BBIQ  |  UC-1V150  |  AZD8848  |  ODN 105870  |  CU-T12-9  |  TLR7/8 agonist 7  |  ODN 21158  |  TH1020

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-131945

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。