MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 112887-68-0
MCE 国际站:Raltitrexed
产品活性:Raltitrexed是一种用于化疗的抗代谢活性分子,通过抑制胸苷酸合成酶起作用。
研究领域:Apoptosis | Cell Cycle/DNA Damage
作用靶点:Thymidylate Synthase | Nucleoside Antimetabolite/Analog
In Vitro: Raltitrexed inhibits HepG2 proliferation by arresting the cell cycle at G0/G1, and the cell cycle is mediated via downregulation of cyclin A and CDK2. Raltitrexed (0.1, 0.5, 2.5 μg/mL) decreases the viability of SGC7901 cells in a dose- and time-dependent manner. Raltitrexed (0.5 μg/mL) shows typical apoptotic morphology, including nuclear shrinkage, fragmentation, chromatin condensation and apoptotic bodies in SGC7901 cells. Raltitrexed blocks the cell cycle at the G0/G1 phase, decreases in the mitochondrial membrane potential. Raltitrexed also increases the level of ROS, induces caspase-3-dependent apoptosis via activation of the mitochondria, and increases TS protein and mRNA expression levels. Raltitrexed (1.5 nM) reduces the number of GM00637 cells, selectively induces gene conversions, but does not affect DSB-induced HR or NHEJ.
In Vivo: Raltitrexed (0, 5, 10, 11.5, 13.5, 15 mg/kg b/w, i.p.) increases the rates of resorbed embryos and growth retardation of murine model of NTDs in a dose dependent manner. Raltitrexed (11.5 mg/kg b/w) maximally inhibits the thymidylate synthase (TS) activity in embryonic tissue, decreases dTMP levels and while increases dUMP levels.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | Peptidomimetic Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Reprogramming Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | FDA Approved & Pharmacopeial Drug Library | Anti-Lung Cancer Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Targeted Diversity Library | Protein-protein Interaction Inhibitor Library | Chemotherapy Drug Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Off-patent Drug Library | 2’-dG (iBu)-2’-phosphoramidite | Peldesine dihydrochloride | 3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine | IBU-DC Phosphoramidite | 8-Methylguanosine | 2'-Deoxy-8-methylamino-adenosine | N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine | 7-Ethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine | 5’-Deoxy-5’-N-methylaminothymidine | N-Acetyl-2′-deoxycytidine | 5-Carboxymethylaminomethyluridine | 3-Deoxy-1,2-O-isopropylidene-5-p-toluoyl-a-D-glycero-pent-3-enofuranose | 3,5-Di-O-benzoyl-2-deoxy-2-fluoro-5-trifluoromethyl-arabinouridine | 6-Mercaptopurine-13C2,15N | 4′,5′-Didehydro-5′-deoxyadenosine | 2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine | 2’-Deoxy-2’-fluoro-N1-methyluridine | 5'-Homocytidine | 2'-Deoxypseudoisocytidine | 3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine | 5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine | 3’,5’-Di-O-benzoyl-2’-deoxy-2’-fluoro-5-methyl-β-D-arabino-uridine | 2’-Deoxy-2’-fluoro-4-thio-beta-D-arabinouridine | 2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]-beta-D-arabinouridine | Uridine triphosphate-13C9,15N2 sodium | 2'-O-Methylinosine | 3-Methylcytidine | Uridine-d | Capecitabine-d11 | 5-Pyrrolidinomethyluridine
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-10821
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。