MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2126136-98-7
MCE 国际站:CCT365623 hydrochloride
产品活性:CCT365623 hydrochloride 是具有口服活性的赖氨酰氧化酶 (LOX) 抑制剂,其IC50 值为0.89 μM。CCT365623 hydrochloride 通过驱动EGF抑制EGFR (pY1068) 和 AKT 的磷酸化。CCT365623 hydrochloride 具有极好的耐受性,良好的药理学特性。
研究领域:Neuronal Signaling | JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | PI3K/Akt/mTOR | TGF-beta/Smad | Stem Cell/Wnt
作用靶点:Monoamine Oxidase | EGFR | Akt | TGF-beta/Smad
In Vitro: CCT365623 inhibits LOX at ~5 μM in the biosensor system.
CCT365623 (0-40 μM) concentration-dependently decreases the protein levels of surface EGFR.
CCT365623 (5 μM) decreases the protein levels of pY1068 EGFR, pAKT and MATN2, and increases the protein levels of pSMAD2.
CCT365623 disrupts HTRA1 multimerization, activates TGFβ1 signalling, suppresses MATN2 expression, suppresses EGFR surface retention, and suppresses EGFR signalling.
In Vivo: CCT365623 displays good stability in mouse liver microsomes and does not inhibit the cardiac potassium channel hERG.
CCT365623 (70 mg/kg, oral gavage per day) significantly delays the development of the primary tumors and also suppresses metastatic lung burden in the animals. CCT365623 disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumor cell.
CCT365623 exhibits a T1/2PO of 0.6 h and F% (oral bioavailability) of 45%.
相关产品:Bioactive Compound Library Plus | EGFR/HER2/CDK9-IN-2 | Lapatinib ditosylate | BMS-690514 | LM22B-10 | Erlotinib-d6 hydrochloride | EGFR/CDK2-IN-1 | Moclobemide N-Oxide | JBJ-04-125-02 | Insulin Detemir | EGFR-IN-22 | (rac)-AG-205 | MAO-B-IN-9 | EGFR-IN-34 | Epertinib | Ponezumab | Hypericin | Lenumlostat | Homopterocarpin | Multi-kinase-IN-2 | Erlotinib Hydrochloride | EGFR-IN-36 | Akt/SKG Substrate Peptide | EGFR-IN-62 | H-Leu-Ser-Lys-Leu-OH | MAO-B-IN-13 | Genistein | AS1949490 | Panitumumab (anti-EGFR) | Disitertide diammonium | (1S,2R)-Tranylcypromine hydrochloride
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-124674A
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。