MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 327036-89-5
MCE 国际站:TDZD-8
产品活性:TDZD-8 是 GSK-3β 的抑制剂,IC50 为 2 μM;TDZD-8 对 Cdk-1/cyclin?B,CK-II,PKA 和 PKC 的作用较弱,IC50 值均 >100 μM。
研究领域:PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点:GSK-3
In Vitro: TDZD8 results in a significant decline of cellular ATP levels in PC-3 cells. TDZD8 (10 μM) treatment also triggers a drastic autophagy response and AMPK activation in PC-3 cells. Furthermore, TDZD8 (10 μM) reduces mTOR phosphorylation levels at the S2448 site. In addition, TDZD8 (10 μM) induces LKB1 nuclear-cytoplasm translocation.
In Vivo: TDZD-8 (TDZD8, 1 or 2 mg/kg, i.p.) both reduces the induction of p-DARPP32 following chronic L-dopa treatment in parkinsonian animals. TDZD8 treatment of 21 days induces a significant reduction in PKA expression in rats with established dyskinesia. Moreover, TDZD8 reduces FosB mRNA level in the striatum and lowers the expression of PPEB mRNA to similar levels as in 6-OHDA-lesioned rats without treated with L-dopa. The decrease in dyskinesia induced by TDZD8 is overcome by dopamine rceptor-1 agonist.
相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glycolysis Compound Library | Cytoskeleton Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Glucose Metabolism Compound Library | Targeted Diversity Library | Antidepressant Compound Library | Human Metabolite Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | BRD5648 | AR-A014418 | GSK-3β inhibitor 3 | SAR502250 | GSK 3 Inhibitor IX | K00546 | GSK-3β inhibitor 10 | DIF-3 | GSK3-IN-2 | RGB-286638 | Laduviglusib (GMP) | ROCK-IN-5 | Indirubin-3′-oxime | GSK-3β inhibitor 2 | Bikinin | Alsterpaullone | GSK3 Substrate, α, β subunit | Indirubin-3'-monoxime | GSK-3 Inhibitor XIII | GSK-3β inhibitor 7 | Aloisine A | Aloisine RP106 | GSK-3β inhibitor 11 | AChE/BACE1/GSK3β-IN-1 | 7BIO | 5-Iodo-indirubin-3'-monoxime | 6-Me-ATP trisodium | 3F8
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-11012
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。