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Cinacalcet

CAS No. : 226256-56-0

MCE 国际站：Cinacalcet

产品活性：Cinacalcet (AMG 073) 是一种可口服的 Ca receptor (CaR) 激动剂，用于心血管疾病研究。

研究领域：GPCR/G Protein  |  Metabolic Enzyme/Protease

作用靶点：CaSR  |  Endogenous Metabolite

In Vivo: Cinacalcet HCl (5 and 10 mg/kg) results in a significant reduction in parathyroid gland weight in 5/6 nephrectomy animals. In sham animals, Cinacalcet HCl has no effect on parathyroid gland cell proliferation or parathyroid weight compared with vehicle treatment. There are no differences in serum phosphorus levels in Cinacalcet HCl (10, 5, or 1 mg/kg) treated 5/6 nephrectomized animals compared with vehicle-treated 5/6 nephrectomized animals. Cinacalcet HCl treatment significantly reduces blood ionized calcium levels in sham animals. Cinacalcet (30 mg/kg/24 h) leads to a marked reduction in circulating parathyroid hormone and a modest reduction in serum Ca. Cinacalcet does not alter UCa when the GHS rats are fed the normal Ca diet but lowers UCa when they are fed the low Ca diet. Cinacalcet does not alter U supersaturation with respect to either CaOx or CaHPO4 on either diet.

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