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CAS No. : 1042224-63-4
MCE 国际站:IRAK inhibitor 1
产品活性:IRAK inhibitor 1 是一种有效的 IRAK-4 抑制剂,IC50 为 216 nM,微弱抑制 JNK-1 和 JNK-2,IC50 分别为 3.801 μM 和 >10 μM。
研究领域:Immunology/Inflammation
作用靶点:IRAK
In Vitro: IRAK inhibitor 1 possesses significant potency in an IRAK-4 enzyme assay but is poorly active against JNK-1 and JNK-2. IRAK-4 is a novel member of the IRAK family with unique functional properties. IRAK-4 is the closest human homolog to Pelle. Endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 can activate NF-κB as well as mitogen-activated protein (MAP) kinase pathways. Most strikingly, and in contrast to the other IRAKs, IRAK-4 depends on its kinase activity to activate NF-κB. In addition, IRAK-4 is able to phosphorylate IRAK-1, and overexpression of dominant-negative IRAK-4 is blocking the IL-1-induced activation and modification of IRAK-1, suggesting a role of IRAK-4 as a central element in the early signal transduction of Toll/IL-1 receptors, upstream of IRAK-1. IRAK-4 shares the domain structure of the other IRAKs and it is able to activate similar signal transduction pathways, namely NF-κB and MAPK pathways. It rapidly and transiently associates with IRAK-1 and TRAF6 in an IL-1-dependent manner but it is not functionally redundant with IRAK-1. IRAK-4 is an active protein kinase and requires its kinase activity to activate NF-κB. IRAK-4 might act upstream of IRAK-1 as an IRAK-1 activator.
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | IRAK4-IN-4 | HS-276 | HS-243 | IRAK inhibitor 2 | IRAK4-IN-14 | HG-12-6 | IRAK4-IN-13 | Zabedosertib | KTX-612 | IRAK inhibitor 6 | KTX-582 | IRAK4-IN-19 | AZ1495 | IRAK4-IN-1 | IRAK4-IN-21 | PROTAC IRAK4 degrader-5 | IRAK4-IN-17 | IRAK4-IN-12 | PROTAC IRAK4 degrader-6 | KTX-951 | IRAK4-IN-22 | IRAK4-IN-11 | JH-X-119-01 hydrochloride | PF-06426779 | JNJ-1013 | IRAK4-IN-16 | Ginsenoside Rb1 | KTX-497 | IRAK-1-4 Inhibitor I
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货号: HY-13275
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