3′-Azido-2′,3′-dideoxyuridine | MedChemExpress (MCE)
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MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。3′-Azido-2′,3′-dideoxyuridineCAS No. : 84472-85-5MCE 国际站：3′-Azido-2′,3′-dideoxyur
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
3′-Azido-2′,3′-dideoxyuridine
CAS No. : 84472-85-5
MCE 国际站：3′-Azido-2′,3′-dideoxyuridine
产品活性：3′-Azido-2′,3′-dideoxyuridine (AzdU) 是一种 Zidovudine (HY-17413) 的核苷类似物。3′-Azido-2′,3′-dideoxyuridine 是一种有效的人类免疫缺陷病毒 (HIV) 抑制剂，可抑制 HIV 在人外周血单个核细胞 (PBMC) 中的复制，对人骨髓细胞 (BMC) 毒性有限。
研究领域：Anti-infection
作用靶点：HIV
In Vitro: 3′-Azido-2′,3′-dideoxyuridine inhibits HIV replication in PBMC infected with HIV-1, with a median effective concentration of 0.18-0.46 μM.
3′-Azido-2′,3′-dideoxyuridine inhibits HIV-mediated cytopathic effects in the human T-cell lines MT-4 and ATH8, with the median effective of 0.4 µM.
3′-Azido-2′,3′-dideoxyuridine is sequentially phosphorylated to its mono-, di-, and triphosphate metabolites by cellular kinases.
In Vivo: 3′-Azido-2′,3′-dideoxyuridine (25-100 mg/kg, IV or PO, once) shows good pharmacokinetic profiles.
Pharmacokinetic Parameters of 3′-Azido-2′,3′-dideoxyuridine in male Sprague-Dawley rats.
| IV (25 mg/kg) | IV (100 mg/kg) | PO (25 mg/kg) | PO (100 mg/kg) | |
| Cmax (μg/mL) | 9.2±1.9 | 41±15 | ||
| Tmax (h) | 0.38±0.13 | 0.63±0.22 | ||
| AUC (μg/mL∗h) | 19±1.2 | 156±7.0 | 12±0.54 | 70±13 |
| CLT (L/h/kg) | 1.4±0.2 | 0.70±0.09 | ||
| CLR (L/h/kg) | 0.90±0.27 | 0.43±0.12 | ||
| t1/2 (h) | 0.5±0.0 | 0.68±0. 相关产品：Bioactive Compound Library Plus | Anti-Infection Compound Library | Antiviral Compound Library | Nucleotide Compound Library | Peldesine dihydrochloride | Abacavir sulfate | HIV-IN-6 | Epicoccone B | Ditiocarb | Nevirapine | DAPTA | Aloperine | Elipovimab | HIV-1 inhibitor-52 | PMEDAP | Integracin B | FNC-TP | DDX3-IN-1 | Sennoside A | CK-666 | HIV-1 inhibitor-44 | Flavopiridol | Claficapavir | Atazanavir | 1-Deoxymannojirimycin hydrochloride | TC14012 | (Z)-9-Propenyladenine | Apabetalone | CCR5 antagonist 2 | 2F5 epitope | HIV-1 inhibitor-23 | Apelin-36(rat, mouse) | MIV-150 | Tenofovir alafenamide hemifumarate 热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学 Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry 货号: HY-106850 品牌介绍:  猜你喜欢
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