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CAS No. : 1390654-28-0
MCE 国际站:KRN2 bromide
产品活性:KRN2 bromide 是选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂,IC50 值为 100 nM。KRN2 bromide 有潜力用于 NFAT5-介导的慢性关节炎的潜能。
研究领域:Immunology/Inflammation
作用靶点:Nuclear Factor of activated T Cells (NFAT)
In Vitro: KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions.
KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1.
In Vivo: KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role.
KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Transcription Factor-Targeted Library | Targeted Diversity Library | Heterocyclic Compound Library | Q134R | CPS-11 | KRM-III | NFAT Inhibitor-1 | Cyclosporin D | KRN2 | NFATc1-IN-1 | 11R-VIVIT | KRN5 | Heraclenin | Gomisin E | INCA-6 | (+)-Syringaresinol
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货号: HY-112125A
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