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Hinokitiol

CAS No. : 499-44-5

MCE 国际站：Hinokitiol

产品活性：Hinokitiol 是从日本扁柏中分离到的挥发油成分，能够降低 Nrf2 的表达，减少 DNMT1 和 UHRF1 的 mRNA 和蛋白的表达，具有抗感染、抗氧化及抗肿瘤等活性。

研究领域：NF-κB  |  Epigenetics  |  Anti-infection

作用靶点：Keap1-Nrf2  |  DNA Methyltransferase  |  Virus Protease

结构分类：酮、醛、酸

来源：植物  |  柏科  |  日本扁柏

In Vitro: In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC₅₀ values of 316.5 ± 35.5 and 152.5 ± 25.3 µM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes.

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