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11-oxo-mogroside V

CAS No. : 126105-11-1

MCE 国际站：11-oxo-mogroside V

产品活性：11-oxo-mogroside V 是一种天然甜味剂，具有很强的抗氧化活性。11-oxo-mogroside V 对活性氧物质具有显着的抑制作用，作用于 O₂^-，H₂O₂ 和 *OH，EC₅₀ 分别为 4.79，16.52 和 146.17 μg/mL。

研究领域：Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Reactive Oxygen Species

结构分类：萜类  |  三萜

来源：植物  |  葫芦科  |  罗汉果

In Vitro: 11-oxo-mogroside V shows a higher scavenging effect on O₂- (concentration at which 50% of chemiluminescence intensity is inhibited [EC₅₀]=4.79 μg/mL) and H₂O₂ (EC₅₀=16.52 μg/mL) than those of mogroside V. 11-oxo-mogroside V exhibits a remarkable inhibitory effect on *OH-induced DNA damage with EC₅₀=3.09 μg/mL.11-oxo-mogroside V, a natural sweetener, isolated from the fruits of Momordica grosvenori, exhibits strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-oxo-mogroside V exhibits strong inhibitory effect on EBV-EA induction (91.2, 50.9 and 21.3% inhibition at 1000, 500 and 100 mol ratio/TPA concentration, respectively).

In Vivo: In the group treated with DMBA, TPA and 11-oxo-mogroside V, only 26.6 and 53.3% of mice bore papillomas even at 10 and 15 weeks of promotion, respectively, and only 1.0 3.3 and 4.7 papillomas are formed per mouse at 10, 15 and 20 weeks of promotion.

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