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PF4V1 Protein, Human (HEK293, Fc)

MCE 国际站：PF4V1 Protein, Human (HEK293, Fc)

PF4V1，也称为 CXCL4L1，是 CXCL4 的非等位基因变体。PF4V1 是一种血小板相关趋化因子，它与肝素的结合比在密切同源物 PF4/CXCL4 中的结合要弱得多。PF4V1 是血管生成抑制剂和内皮细胞趋化性抑制剂。PF4V1 与炎症、血管生成和癌症有关。PF4V1 Protein, Human (HEK293, Fc) 在 HEK293 细胞中产生，带有 C 末端 Fc 标记。它由 104 个氨基酸 (M1-S104) 组成。

Synonyms: Platelet factor 4 variant; CXCL4L1; PF4var1; SCYB4V1

Species: Human

Source: HEK293

Biological Activity: Measured by its ability to inhibit proliferation of HUVEC human umbilical vein endothelial cells. The ED₅₀ of this effect is 37.49 ng/mL, corresponding to a specific activity is 2.67×10⁴ units/mg.

研究背景：PF4V1 (CXCL4L1), a CXC chemokine, is originally isolated from thrombin stimulated platelets. Full-length human CXCL4L1/PF-4var is comprised of 104 amino acids. CXCL4L1 seems to be constitutively released by platelets, smooth muscle cells, human aortic and coronary smooth muscle cells and is inducible in monocytes, endothelial and osteosarcoma cells by inflammatory mediators. CXCL4L1 plays a role in inflammation, angiogenesis and cancer.
CXCL4 and its non-allelic variant CXCL4L1 are both platelet-derived chemokines. The mature CXCL4L1 protein is composed of 70 amino acids and differs in only three amino acids situated in the carboxy-terminal part of the protein (Pro58 ) Leu, Lys66 ) Glu, Leu67 ) His; CXCL4 ) CXCL4L1). Due to these changes in amino acids, CXCL4L1 is supposed to have a different secondary structure and a lower affinity for heparin. In vivo, weak to strong expression of CXCL4L1 was detected in sarcoma tissue by immunohistochemistry. CXCL4L1 functions as a chemoattractant for activated T cells, NK cells and immature dendritic cells. CXCL4L1 is a more potent angiostatic chemokine compared to CXCL4. Compared to CXCL4, CXCL4L1 is less likely to form heterodimers with fFGF2 and VEGF or to compete for GAG-binding.
CXCL4L1 is found to be a more potent angiostatic and anti-tumoral chemokine compared to CXCL4 in various in vitro and in vivo assays. CXCL4L1 (10 ng/mL) is more potent than CXCL4 in inhibiting CXCL8/IL-8- or FGF-2-induced chemotaxis of endothelial cells. Further, CXCL4L1 is induced in human osteosarcoma cells (1.5-3.5 ng/mL) by IL-1β, TNF-α and IL-17A. CXCL4L1 is expressed and functioned in several cancers such as ovarian carcinoma, breast cancer, and pancreatic cancer. Additionally, CXCL4L1 is also strongly detected in colorectal carcinoma tissue samples, whereas CXCL4L1 staining in squamous cell carcinoma of the esophagus is weak to negative.

蛋白编号：NP_002611.1 (F31-S104)

基因 ID：5197

产品分类：细胞因子和生长因子  |  趋化因子  |  CXC 趋化因子  |  CXC 趋化因子配体 4 变体 1

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CXC Chemokines  |  Platelet Factor 4 Variant 1

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