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CAS No. : 1420-04-8
MCE 国际站:Niclosamide olamine
产品活性:Niclosamide (BAY2353) olamine 是一种具有口服活性的用于寄生虫感染研究的抗蠕虫化合物。Niclosamide olamine 是 STAT3 抑制剂,在 HeLa 细胞中的 IC50 为 0.25 μM。Niclosamide olamine 具有抗癌的生物活性,并能抑制 Vero E6 细胞的 DNA 复制。
研究领域:JAK/STAT Signaling | Stem Cell/Wnt | Anti-infection
作用靶点:STAT | Parasite | Antibiotic
In Vitro: Niclosamide olamine (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells.Niclosamide olamine (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells .Niclosamide olamine (10 μM) treatment inhibits virus replication in Vero E6 cells.
In Vivo: Niclosamide sodium (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo.
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