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Diltiazem

CAS No. : 42399-41-7

MCE 国际站：Diltiazem

产品活性：Diltiazem 是一种口服 L 型钙通道 (L-type Ca²⁺ channel) 阻滞剂。 Diltiazem 具有抗高血压和抗心律失常作用。Diltiazem 可用于心律失常、高血压和心绞痛的研究。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: Diltiazem (200 µM) elicits a use-dependent blockade that proceeded within a relatively small number of pulses.
Diltiazem reduces Ca²⁺ influx by accelerating inactivation during action potentials, and that the use-dependent blockade is due to increases in the number of channels in a sustained closed state.

In Vivo: Diltiazem (100 mg/kg; p.o.; for 4 weeks) prevents aortic aneurysm formation in a blood pressure-independent manner.
Diltiazem limits aortic aneurysm formation in mice by a blood pressure-independent anti-inflammatory effect on monocytic cells.
Diltiazem (2 mg/kg; i.v.) exhibits T_1/2 of 61.2 min, CL_el of 3.2 mL/min in rats.

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