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VEGF164 Protein, Mouse

MCE 国际站：VEGF164 Protein, Mouse

VEGF164 Protein, Mouse是一个有效的血管生成调节剂，并能与信号蛋白受体neuropilin1 结合。

Synonyms: VEGF-AA; rMuVEGF164; VPF

Species: Mouse

Source: E. coli

Biological Activity: The ED₅₀ is <5 ng/mL as measured by human umbilical vein endothelial cells(HUVEC), corresponding to a specific activity of >2.0 × 10⁵ units/mg.

研究背景：VEGF164 was found to be significantly more potent at inducing inflammation. In vivo blockade of VEGF receptor (VEGFR)-1 significantly suppressed VEGF164-induced corneal inflammation. In vitro, VEGF164 more potently stimulated intracellular adhesion molecule (ICAM)-1 expression on endothelial cells, an effect that was mediated by VEGFR2. VEGF164 was also more potent at inducing the chemotaxis of monocytes, an effect that was mediated by VEGFR1. In an immortalized human leukocyte cell line, VEGF164 was found to induce tyrosine phosphorylation of VEGFR1 more efficiently. VEGF164 is an important isoform in the pathogenesis of early diabetic retinopathy.

蛋白编号：Q00731-2 (A27-R190)

基因 ID：22339

产品分类：细胞因子和生长因子  |  血管内皮生长因子及受体  |  血管内皮生长因子  |  血管内皮生长因子 A

Categories：Cytokines and Growth Factors  |  VEGF & VEGFR  |  VEGF  |  VEGF-A

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