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Activin A Protein, Mouse (HEK 293, His)

MCE 国际站：Activin A Protein, Mouse (HEK 293, His)

Activin A 是一种多功能细胞因子，是 TGF-β 超家族的成员。Activin A 首先与成员表面的 II 型激活素受体(ActIIRA 或 ActRIIB) 结合，然后募集和磷酸化 I 型激活素受体 (ActRI)。Activin A 主要通过 SMAD2/3 蛋白发出信号以调节多种功能，包括炎症、纤维化和肿瘤发生。Activin A Protein, Mouse (HEK293, His) 在 HEK293 细胞中表达产生，由 424 个氨基酸 (M1-S424) 组成，其 C 末端带有 His 标签。

Synonyms: Activin beta-A chain; Activin A; Inhibin beta A chain; INHBA

Species: Mouse

Source: HEK293

研究背景：Activin is a member of transforming growth factor-β (TGF-β) superfamily consisting of two inhibin β subunits linked by disulfide bonds. Activin A is expressed widely in various tissues and cells with strong bioactivities and is the mostly studied activin.
The sequence of amino acids in Activin A proteins from different species is very stable, which leads to the conclusion that in the process of evolution, Activin A has been only slightly altered, and that both in humans and in animals, its function is similar.
Activin exists in three basic molecular forms composed of two inhibin β subunits: activin A (βAβA), activin B (βBβB), and activin AB (βAβB). Activin A binds with high affinity to activin type II receptors, which recruit type I receptors and are necessary for the activation of Smad2/3 signaling. The phosphorylated ActRI activates Smad2 and Smad3, which form a complex with Smad4 to translocate to the nucleus. Activin and TGF-β share the same signaling pathway at the level of Smad2/3/4. Activin A exerts a variety of biological functions including regulation of hematopoietic cell proliferation, neuron differentiation, pituitary hormone secretion, and tissue repair. It is also involved in the process of many diseases, for example, inflammation, fibrosis and tumorigenesis.
Activin A has pro- and anti-tumorigenic functions depending on the tumor type. In breast, liver and colon cancers, activin signals were revealed to inhibit tumor cell growth. In addition, tumor tissues were revealed to express decreased levels of activin A or increased levels of activin antagonists or demonstrated the downregulation of activin receptors or Smad proteins. Moreover, its roles include embryonic differentiation, trophoblast invasion of the uterine wall in early pregnancy, and fetal/neonate brain protection in hypoxic conditions. Activin A also regulates bone formation and regeneration, enhances joint inflammation in rheumatoid arthritis, and triggers pathogenic mechanisms in the respiratory system.

蛋白编号：Q3UY39 (S21-S424)

基因 ID：16323

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  激活素/抑制素  |  激活素 A

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Activin/Inhibins  |  Activin A

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