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MCP-1/CCL2 Protein, Human

MCE 国际站：MCP-1/CCL2 Protein, Human

MCP-1/CCL2 Protein, Human 是属于 CC 趋化因子家族的细胞因子，可以与细胞表面的CCR2趋化因子受体相互作用，介导炎症免疫反应、病毒感染以及肿瘤发生等。MCP-1/CCL2 Protein, Human 是一种由E.coil 表达的重组人 MCP-1/CCL2 (Q24-T99) 蛋白。

Synonyms: rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2

Species: Human

Source: E. coli

Biological Activity: 1.The ED₅₀ is <1 μg/mL as measured by CHO-K1/Gα15/hCCR2 cells (human Gα15 and human CCR2 stably expressed in CHO-K1 cells).
2.Measured by its ability to chemoattract THP-1 human acute monocytic leukemia cells. The ED₅₀ this effect is 48.89 ng/mL, corresponding to a specific activity is 2.05×10⁴ U/mg.

研究背景：CCL2, also known as monocyte chemotactic protein 1 (MCP1), is a small cell factor belonging to the CC chemokine family. The CCL2 gene, located in the q11.2-q12 region of human chromosome 17, encodes a monomeric polypeptide with a molecular weight of 9-15 kDa, depending on the level of glycosylation. CCL2 is mainly secreted by monocytes, macrophages and dendritic cells. It is secreted by monocytes, macrophages and dendritic cells, and platelet-derived growth factor is the main inducer of the CCL2 gene. Astrocytes and microglia are also thought to be the source of CCL2. CCL2 signals through binding to and activation of CCR2 and induces a strong chemotactic response and intracellular mobilization of calcium ions. Among other things, CCL2/CCR2 can regulate cell adhesion and chemotaxis of macrophages by activating the β1 integrin and p38-MAPK signaling pathways. In addition to acting as a chemoattractant, CCL2 can also regulate brain endothelial permeability in vitro by altering tight junction (TJ) proteins and regulating the expression of endothelial adhesion molecules and leukocyte integrins as well as cytokine production. In addition, the CCL2-CCR2 signaling axis has been implicated in many inflammatory and neurodegenerative diseases, acting to recruit inflammatory cells into the CNS.  Originally described as a "tumor-derived chemokine", CCL2 has been shown to be a potent chemokine for many types of immune cells and a potential target for the treatment of many diseases, such as atherosclerosis, multiple sclerosis, asthma, neuropathic pain, diabetic nephropathy, and cancer.

蛋白编号：P13500 (Q24-T99)

基因 ID：6347

产品分类：细胞因子和生长因子  |  趋化因子  |  CC 趋化因子  |  趋化因子 CCL2

Categories：Cytokines and Growth Factors  |  Chemokine & Receptors  |  CC Chemokines  |  MCP-1/CCL2

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