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CAS No. : 137061-46-2
MCE 国际站:Nisin Z
产品活性:Nisin Z 是一种抗菌和抗炎肽。Nisin Z 可有效对抗革兰氏阳性菌和真菌 (fungi),例如 C. albicans。
研究领域:Anti-infection
作用靶点:Bacterial | Fungal
In Vitro: Nisin Z (10 μg/mL, 24 h) increases gingival fibroblasts detachment and differentiation.
Nisin Z (25-75 μg/mL, 24 h) decreases C. albicans adhesion to the gingival cells.
Nisin Z (500 and 1000 μg/mL, 24 h) inhibits germ tube formation by C. albicans.
Nisin Z (100 μg/mL, 12 h) reduces the production of LPS-induced pro-inflammatory cytokines (i.e., IL-6, TNF-α, IL-1β) in MCF10A cells.
Nisin Z (10-100 μg/mL, 12 h) inhibits the activation of the ERK1/2 and p38 MAPK signaling pathway in LPS-induced MCF10A cells.
In Vivo: Nisin Z (1, 5, and 10 mg/kg, i.p.) prevents the pathological damage in mastitis mouse mode caused by LPS.
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