耗材描述
LH-RH (7-10)
产品活性:LH-RH (7-10) 是一种四肽,性腺激素释放激素 (LHRH) 经垂体和下丘脑降解的主要降解产物之一。LH-RH (7-10) 在巨噬细胞、I 型样和 II 型肺细胞中产生。
产品来源: https://www.medchemexpress.cn/lh-rh-7-10.html
研究领域:GPCR/G Protein
作用靶点:GnRH Receptor
In Vitro: The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and
Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor).
LH-RH (7-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 1.7 nM.
In Vivo: LH-RH (7-10) (i.v.) increases esterase activity in plasma kinin system in rats.
LH-RH (7-10) (ntracarotid infusion i.v.; single dose) stimulates a significant increase in plasma LH concentration in the jugular vein.
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