耗材描述
IKKγ NBD Inhibitory Peptide TFA
产品活性:IKKγ NBD 抑制肽 TFA 是一种高度特异性的 NF-κB 抑制剂。IKKγ NBD 抑制肽 TFA 通过阻断 IKKγ/NEMO 结合域 (NBD) 与 IKKα 和 IKKβ 之间的相互作用,而阻断 TNF-α 诱导的 NF-κB 激活。IKKγ NBD 抑制肽 TFA 可显著降低炎症、改善脑缺血所致的神经功能缺损。
产品来源: https://www.medchemexpress.cn/ikkγ-nbd-inhibitory-peptide-tfa.html
研究领域:NF-κB
作用靶点:NF-κB
In Vitro: In a canonical pathway, NF kappa B activation depends on the IKK complex activity, which is formed by three subunits (IKKκ and IKKβ and IKKγ/NEMO), thus the KKγ NBD Inhibitory Peptide TFA inhibits TNF-α-induced NF-kB activation.
IKKγ NBD Inhibitory Peptide TFA (10 μM; 90 min) prevents Doxorubicin (HY-15142A)-induced (15 μM; 4 h) p65 phosphorylation in BT-474 cells.
IKKγ NBD Inhibitory Peptide TFA (10 μM; 48 h) slightly inhibits BT-474 cell viability while it markedly enhances the effects on Doxorubicin.
In Vivo: IKKγ NBD Inhibitory Peptide TFA (40 μg/4 μL; ICV; single dose; 2 h before MCAO) exhibits neuroprotective effect with reduction in DNA fragmentation, and its ischemic brain damage reduction mechanism be attributed to reduction in inflammation following ischemic injury in middle cerebral artery occlusion (MCAO) rats model.
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